Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp177 | Chondrocytes and cartilage | ECTS2014

The transcription factor Foxc1 controls endochondral ossification through the direct regulation of PTHrP and Cola10a1 expression under the partnership with Gli2 and Runx2

Yoshida Michiko , Hata Kenji , Takashima Rikako , Iseki Sachiko , Yamamoto-Takano Teruko , Nishimura Riko , Yoneda Toshiyuki

Endochondral ossification is regulated by various transcription factors in a temporo-spatial manner. Identification of novel transcription factors involved in chondrogenesis would facilitate to uncover the molecular basis of endochondral ossification. To approach this, we generated transgenic mice in which chondrocytes were specifically fluorescence-labeled with Venus gene using Col2a1 gene promoter, thereby allowing us to isolate Venus-positive chondrogenic cells using FACS A...